Mounjaro (tirzepatide) is a powerful weekly injection used to treat type 2 diabetes and support weight loss. It’s known for helping people shed significant amounts of weight — but like any medication, it can cause side effects.
If you’re considering using Mounjaro through a regulated provider like PPRX, it’s essential to understand both the common and rare side effects before starting your journey.
Common Side Effects of Mounjaro
These are the most frequently reported side effects, especially in the first few weeks of use:
- Nausea
- Vomiting
- Diarrhoea
- Constipation
- Stomach pain or bloating
- Reduced appetite
- Indigestion or heartburn
These symptoms are usually mild to moderate and tend to improve over time, particularly once your body adjusts to the treatment. Starting at a lower dose and increasing gradually can significantly reduce these issues.
At PPRX, we provide full instructions to help you ease into treatment and minimise discomfort.
Less Common Side Effects
Some people experience:
- Headache
- Fatigue or low energy
- Dizziness
- Injection site reactions (e.g., redness, itching)
These are generally short-lived and can be managed with rest, hydration, and dose monitoring.
Rare but Serious Side Effects
Although very rare, you should be aware of potential serious effects:
- Pancreatitis – Sudden, severe stomach pain that may radiate to the back.
- Gallbladder issues – Including gallstones or gallbladder inflammation.
- Kidney problems – Usually only in those with pre-existing conditions.
- Allergic reactions – Such as rash, swelling, or breathing difficulties.
If you experience any of these, stop using the medication and seek medical help immediately.
Who Should Avoid Mounjaro?
You should not take Mounjaro if you:
- Are pregnant or breastfeeding
- Have a personal or family history of medullary thyroid cancer
- Have multiple endocrine neoplasia syndrome type 2 (MEN2)
Always complete a full medical assessment — like the one provided at PPRX — before starting Mounjaro.
Tips to Reduce Side Effects
- Eat smaller meals and avoid greasy, spicy foods.
- Inject at the same time each week to maintain stable blood levels.
- Stay hydrated, especially if you experience diarrhoea or nausea.
- Follow dosage instructions carefully, starting low and titrating up.
We offer ongoing support to all PPRX patients to help them manage side effects and stay on track.
While Mounjaro can cause some initial discomfort, the side effects are usually manageable — especially with professional guidance. The benefits for weight loss and metabolic health often far outweigh the temporary issues.
To begin your safe and supported Mounjaro journey, visit PPRX today

At PPRX UK, we provide:
- Genuine Mounjaro pens, sourced directly from the manufacturer (Eli Lilly)
- Dispensing via a GPhC-registered UK pharmacy
- Professional consultations with UK pharmacists
- Ongoing support, dosage guidance, and repeat supply options
Whether you’re just starting or switching from Ozempic or Wegovy, we’re here to help.

📞 Get in Touch
Visit www.pprx.co.uk or contact us directly to begin your online consultation.
We offer fast, discreet UK-wide delivery and exceptional support throughout your journey.
Mounjaro is a prescription-only medicine. This article is for informational purposes only and does not replace medical advice. Always consult a qualified healthcare provider before starting treatment. nhs